VIP – COMPREHENSIVE RESEARCH PEPTIDE FOR NEUROENDOCRINE AND IMMUNE SIGNALING STUDIES

Scientific Overview of VIP

Vasoactive Intestinal Peptide (VIP) is a 28-amino-acid neuropeptide widely distributed throughout the central nervous system, gastrointestinal tract, and peripheral tissues. It plays a central role in neuroendocrine communication and immune regulation.

In experimental research, VIP has been investigated for its influence on:

• Neuropeptide Receptor Signaling – activation of VPAC1 and VPAC2 receptors and downstream cAMP-mediated pathways (Harmar et al., 2012)
• Immune and Inflammatory Modulation – study of cytokine regulation and immune cell signaling in inflammatory models (Delgado et al., 2004)
• Smooth Muscle and Vascular Regulation – evaluation of peptide effects on vasodilation and bronchial smooth muscle relaxation (Said, 2007)

VIP is a critical research peptide for understanding neuroimmune interactions, endocrine signaling, and peptide-mediated homeostatic regulation.